Animal Models: Recent HKUST Research

Prof. JY Qu:

Zhongya Qin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo and Jianan Y. Qu (2018). New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms. Biomedical Optics Express. 9:3374-90.

Prof. Nancy Ip:

Gu S, Fu WY, Fu AKY, Tong EPS, Ip FCF, Huang X, Ip NY (2018). Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs. Sci Rep. 8:7377. doi: 10.1038/s41598-018-25790-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943255/

Prof. Jun Xia:

Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J (2018). Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 23:1691-1705. doi: 10.1016/j.celrep.2018.04.015. https://www.ncbi.nlm.nih.gov/pubmed/29742426

Prof. Karl Herrup:

Tse KH, Cheng A, Ma F, Herrup K (2018). DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia. Alzheimers Dement. 14:664-679. doi: 10.1016/j.jalz.2017.11.010. https://www.ncbi.nlm.nih.gov/pubmed/29328926

Prof. King Chow:

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK5, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS (2018). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. 67:931-944. doi: 10.1136/gutjnl-2017-314032. https://www.ncbi.nlm.nih.gov/pubmed/28939663

Prof. JY Qu and Z Wu:

He S, An Y, Li X, Wei X, Sun Q, Wu Z, Qu JY (2018). In vivo metabolic imaging and monitoring of brown and beige fat. J Biophotonics. doi: 10.1002/jbio.201800019.  https://www.ncbi.nlm.nih.gov/pubmed/29521002

Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo and Jianan Y. Qu (2018). In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues. Biomedical Optics Express. 9:581-90.

Prof. BZ Tang:

Qi J, Sun C, Zebibula A, Zhang H, Kwok RTK, Zhao X, Xi W, Lam JWY, Qian J, Tang BZ (2018).
Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region. Adv Mater. 30(12):e1706856. doi: 10.1002/adma.201706856.  https://www.ncbi.nlm.nih.gov/pubmed/29341330

Prof. Herrup:

Tse KH, Cheng A, Ma F, Herrup K. (2018). DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s and dementia. Alzheimers Dement. pii: S1552-5260(17)33853-0. https://www.ncbi.nlm.nih.gov/pubmed/29328926

Prof. Jun Xia:

Li J, Mao Z, Huang J, Xia J (2018). PICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis. Mol Biol Cell. pii: mbc.E17-03-0204. https://www.ncbi.nlm.nih.gov/pubmed/29298842

Prof. Hyokeun Park:

Alsina A, Lai WM, Wong WK, Qin X, Zhang M, Park H (2017). Real-time subpixel-accuracy tracking of single mitochondria in neurons reveals heterogeneous mitochondrial motion. Biochem Biophys Res Commun. 493:776-782. https://www.ncbi.nlm.nih.gov/pubmed/28882593

Prof. Tom Cheung and Prof. Nacy Ip: 

Ip FCF, Ng YP, Or TCT, Sun P, Fu G, Li JYH, Ye WC, Cheung TH, Ip NY (2017) Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response. PLoS One. 12:e0182069. https://www.ncbi.nlm.nih.gov/pubmed/28759648

Prof. King L Chow: 

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS (2017). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. pii: gutjnl-2017-314032. https://www.ncbi.nlm.nih.gov/pubmed/28939663

Prof. Robert KM Ko:

Chen J, Wong HS, Leong PK, Leung HY, Chan WM, Ko KM. (2017). Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance. Food Funct. 8:2425-2436. https://www.ncbi.nlm.nih.gov/pubmed/28675237

Prof. Hong Xue:

Li R, Chan W, Mat W, Ho Y, Yeung RK, Tsang S, Xue H.(2017). Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs. Evid Based Complement Alternat Med. 2017;2017:4624069. http://hdl.handle.net/1783.1/83864

Prof. Pingbo Huang:

Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P. (2017). The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. Elife. 6;e28021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503512/

Prof. Jianan Qu:

He S, Xue W, Duan Z, Sun Q, Li X, Gan H, Huang J, Qu JY (2017). Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development. Biomed Opt Express. 8:1771-1782. https://www.ncbi.nlm.nih.gov/pubmed/28663865 

Prof. Robert Ko: 

Leong PK, Chen J, Chan WM, Leung HY, Chan L, Ko KM (2017). Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo. Antioxidants (Basel). 10;6(2). pii: E28
https://www.ncbi.nlm.nih.gov/pubmed/28394280

Prof. Karl Herrup: 

Tse KH and Herrup K (2017). DNA damage in the oligodendrocyte lineage and its role in brain aging. Mech Ageing Dev. 161:37-50.
https://www.ncbi.nlm.nih.gov/pubmed/27235538

Profs. Tom Cheung, Nancy Ip and ZG Wu: 

An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, and Wu Z (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 41: 382-91. https://www.ncbi.nlm.nih.gov/pubmed/28535373

Prof. Liu Kai: 

Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K (2016). Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proceedings of the National Academy of Sciences. 16;113:1937-42.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763730/