Animal Models: Recent HKUST Research


Prof. Herrup:

Tse KH, Cheng A, Ma F, Herrup K. (2018). DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s and dementia. Alzheimers Dement. pii: S1552-5260(17)33853-0.

Prof. Jun Xia:

Li J, Mao Z, Huang J, Xia J (2018). PICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis. Mol Biol Cell. pii: mbc.E17-03-0204.

Prof. Hyokeun Park:

Alsina A, Lai WM, Wong WK, Qin X, Zhang M, Park H (2017). Real-time subpixel-accuracy tracking of single mitochondria in neurons reveals heterogeneous mitochondrial motion. Biochem Biophys Res Commun. 493:776-782.

Prof. Tom Cheung and Prof. Nacy Ip: 

Ip FCF, Ng YP, Or TCT, Sun P, Fu G, Li JYH, Ye WC, Cheung TH, Ip NY (2017) Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response. PLoS One. 12:e0182069.

Prof. King L Chow: 

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS (2017). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. pii: gutjnl-2017-314032.

Prof. Robert KM Ko:

Chen J, Wong HS, Leong PK, Leung HY, Chan WM, Ko KM. (2017). Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance. Food Funct. 8:2425-2436.

Prof. Hong Xue:

Li R, Chan W, Mat W, Ho Y, Yeung RK, Tsang S, Xue H.(2017). Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs. Evid Based Complement Alternat Med. 2017;2017:4624069.

Prof. Pingbo Huang:

Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P. (2017). The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. Elife. 6;e28021.

Prof. Jianan Qu:

He S, Xue W, Duan Z, Sun Q, Li X, Gan H, Huang J, Qu JY (2017). Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development. Biomed Opt Express. 8:1771-1782. 

Prof. Robert Ko: 

Leong PK, Chen J, Chan WM, Leung HY, Chan L, Ko KM (2017). Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo. Antioxidants (Basel). 10;6(2). pii: E28

Prof. Karl Herrup: 

Tse KH and Herrup K (2017). DNA damage in the oligodendrocyte lineage and its role in brain aging. Mech Ageing Dev. 161:37-50.


Profs. Tom Cheung, Nancy Ip and ZG Wu: 

An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, and Wu Z (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 41: 382-91.


Prof. Liu Kai: 

Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K (2016). Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proceedings of the National Academy of Sciences. 16;113:1937-42.














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