Publications of APCF Users


The following is listing the publications involving the usage of services provided by APCF

(Publications are grouped by Principal Investigators’ names according to their contributions using services provided by APCF)


Prof. PB Huang

Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice.
Li X, Yu X, Chen X, Liu Z, Wang G, Li C, Wong EYM, Sham MH, Tang J, He J, Xiong W, Liu Z, Huang P.
FASEB J. 2019 Feb 26:fj201802155RR. doi: 10.1096/fj.201802155RR. 

Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function.
Yang X, Zhou S, Wu J, Liao Q, Wang C, Liu M, Qu L, Zhang Y, Cheng C, Chai R, Zhang K, Yu X, Huang P, Liu L, Xiong W, Chen S, Chen F.
Neurosci Lett. 2019 Mar 23;696:212-218. doi: 10.1016/j.neulet.2018.12.036. 

Prof. Kai Liu

Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration.
Wang H, Wang X, Zhang K, Wang Q, Cao X, Wang Z, Zhang S, Li A, Liu K, Fang Y.
Sci Adv. 2019 Feb 13;5(2):eaav4971. doi: 10.1126/sciadv.aav4971. eCollection 2019 Feb.

Prof. Nancy Ip

Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect.
Chen WW, Fu WY, Su YT, Fang WQ, Fu AKY, Ip NY.
Sci Rep. 2019 Feb 4;9(1):1190. doi: 10.1038/s41598-018-38103-3.

Profs. JY Qu ad Nancy Ip

In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of Alzheimer’s Disease Mouse Model.
Chen C, Liang Z, Zhou B, Li X, Lui C, Ip NY, Qu JY.
ACS Chem Neurosci. 2018 Aug 16. doi: 10.1021/acschemneuro.8b00306.

Prof. King Chow

Generation and characterization of pathogenic Mab21l2(R51C) mouse model.
Tsang SW, Guo Y, Chan LH, Huang Y, Chow KL.
Genesis. 2018 Dec;56(11-12):e23261. doi: 10.1002/dvg.23261.

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.
Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL.
Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8.

Prof. Hyokeun Park

Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease.
Chen S, Yu C, Rong L, Li CH, Qin X, Ryu H, Park H.
Front Mol Neurosci. 2018 Dec 24;11:478. doi: 10.3389/fnmol.2018.00478. eCollection 2018.

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease.
Yu C, Li CH, Chen S, Yoo H, Qin X, Park H.
Sci Rep. 2018 Nov 19;8(1):16976. doi: 10.1038/s41598-018-34883-w.

Prof. Karl Herrup

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice.
Hui CW, Song X, Ma F, Shen X, Herrup K.
J Neuroinflammation. 2018 Nov 6;15(1):308. doi: 10.1186/s12974-018-1338-7.

Prof. Ying Chau

Polymeric nanoparticles decorated with BDNF-derived peptide for neuron-targeted delivery of PTEN inhibitor.
Xu J, Chau Y.
Eur J Pharm Sci. 2018 Nov 1;124:37-45. doi: 10.1016/j.ejps.2018.08.020. 

Prof. PY Qian

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining.
Li YX, Zhong Z, Zhang WP, Qian PY.
Nat Commun. 2018 Aug 16;9(1):3273. doi: 10.1038/s41467-018-05781-6. 

Prof. Hong Xue

Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation.
Yeung RK, Xiang ZH, Tsang SY, Li R, Ho TYC, Li Q, Hui CK, Sham PC, Qiao MQ, Xue H.
Transl Psychiatry. 2018 Jul 17;8(1):128. doi: 10.1038/s41398-018-0176-9.

Prof. Jun Xia

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
He J, Xia M, Yeung PKK, Li J, Li Z, Chung KK, Chung SK, Xia J.
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7193-E7201. doi: 10.1073/pnas.1716506115.


Prof. JY Qu

Zhongya Qin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo and Jianan Y. Qu (2018). New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms. Biomedical Optics Express. 9:3374-90.

Prof. Nancy Ip

Gu S, Fu WY, Fu AKY, Tong EPS, Ip FCF, Huang X, Ip NY (2018). Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs. Sci Rep. 8:7377. doi: 10.1038/s41598-018-25790-1.

Prof. Jun Xia

Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J (2018). Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 23:1691-1705. doi: 10.1016/j.celrep.2018.04.015.

Prof. Karl Herrup

Tse KH, Cheng A, Ma F, Herrup K (2018). DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia. Alzheimers Dement. 14:664-679. doi: 10.1016/j.jalz.2017.11.010.

Prof. King Chow

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK5, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS (2018). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. 67:931-944. doi: 10.1136/gutjnl-2017-314032.

Prof. JY Qu and Z Wu

He S, An Y, Li X, Wei X, Sun Q, Wu Z, Qu JY (2018). In vivo metabolic imaging and monitoring of brown and beige fat. J Biophotonics. doi: 10.1002/jbio.201800019.

Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo and Jianan Y. Qu (2018). In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues. Biomedical Optics Express. 9:581-90.

Prof. BZ Tang

Qi J, Sun C, Zebibula A, Zhang H, Kwok RTK, Zhao X, Xi W, Lam JWY, Qian J, Tang BZ (2018).
Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region. Adv Mater. 30(12):e1706856. doi: 10.1002/adma.201706856.

Prof. Herrup

Tse KH, Cheng A, Ma F, Herrup K. (2018). DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s and dementia. Alzheimers Dement. pii: S1552-5260(17)33853-0.

Prof. Jun Xia

Li J, Mao Z, Huang J, Xia J (2018). PICK1 is Essential for Insulin Production and the Maintenance of Glucose Homeostasis. Mol Biol Cell. pii: mbc.E17-03-0204.

Prof. Hyokeun Park

Alsina A, Lai WM, Wong WK, Qin X, Zhang M, Park H (2017). Real-time subpixel-accuracy tracking of single mitochondria in neurons reveals heterogeneous mitochondrial motion. Biochem Biophys Res Commun. 493:776-782.

Prof. Tom Cheung and Prof. Nancy Ip:

Ip FCF, Ng YP, Or TCT, Sun P, Fu G, Li JYH, Ye WC, Cheung TH, Ip NY (2017) Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response. PLoS One. 12:e0182069.

Prof. King L Chow

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS (2017). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. pii: gutjnl-2017-314032.

Prof. Robert KM Ko

Chen J, Wong HS, Leong PK, Leung HY, Chan WM, Ko KM. (2017). Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance. Food Funct. 8:2425-2436.

Prof. Hong Xue

Li R, Chan W, Mat W, Ho Y, Yeung RK, Tsang S, Xue H.(2017). Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs. Evid Based Complement Alternat Med. 2017;2017:4624069.


Prof. Pingbo Huang

Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P. (2017). The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. Elife. 6;e28021.

Prof. Jianan Qu

He S, Xue W, Duan Z, Sun Q, Li X, Gan H, Huang J, Qu JY (2017). Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development. Biomed Opt Express. 8:1771-1782. 

Prof. Robert Ko

Leong PK, Chen J, Chan WM, Leung HY, Chan L, Ko KM (2017). Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo. Antioxidants (Basel). 10;6(2). pii: E28

Prof. Karl Herrup

Tse KH and Herrup K (2017). DNA damage in the oligodendrocyte lineage and its role in brain aging. Mech Ageing Dev. 161:37-50.

Profs. ZG Wu

An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, and Wu Z (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 41: 382-91.

Prof. Liu Kai

Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K (2016). Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proceedings of the National Academy of Sciences. 16;113:1937-42.